THE INTRODUCTION OF THIS GROUP
The research group of Novel Materials and Methods for Separation and Detection of Biomolecules has about 30 members including 8 staff scientists and more than 20 graduate students. This group was founded by Prof. Hanfa Zou and now is headed by Dr. Mingliang Ye. The mission for this group is to develop novel proteomics methods to enhance the understanding of protein functions, and finally leading to the discovery of new biomarkers for the diagnosis of disease and new target proteins to cure diseases (Refer to the representative works for detail). A variety of new proteomics methods have been developed to analyze the post-translational modifications of proteins, which regulate the functions of proteins. Several modification-free target protein identification methods are developed to elucidate the drug action of mechanism and to understand the potential side effects of drugs.
THE INTRODUCTION OF GROUP LEADER
Prof. Mingliang Ye
Division of Biotechnology,
Dalian Institute of Chemical Physics,
Chinese Academy of Sciences,
Dalian 116023, China
Tel/Fax: 0086-411-84379620
Email: mingliang@dicp.ac.cn
Dr. Mingliang Ye obtained his Ph D degree under the supervision of Prof. Hanfa Zou at the Dalian Institute of Chemical Physics (DICP), Chinese Academy of Science (CAS), in 2001, and worked as postdoctoral fellows under supervision of Prof. Norman Dovichi at the University of Washington, USA (2001.11-2003.3), and Prof. Reudi Aebersold at the Institute for System Biology, USA (2003.3-2004.10). In November of 2004, he came back to China and now he is a full professor in DICP. He published more than 200 peer-reviewed papers in SCI journals ( google scholar for full list). He won Excellent Young Scientist Funding awarded by the National Natural Science Foundation of China in 2015. Currently his research interests are mainly focused on developing new proteomics methods for the analysis of protein post-translational modifications and for the identification of target proteins of diverse ligands.
Research Experience
1992-1996, Anhui Normal University, Wuhu, China
Undergraduate student in Cheimstry
1996-2001, Dalian Institute of Chemical Physics, CAS, Dalian, China
Ph.D student in Analytical Chemistry under supervision of Prof. Hanfa Zou
2001-2003, University of Washington, Seattle, USA,
Post-doctoral fellow working with Prof. Norman Dovichi
2003-2004, Institute for Systems Biology, Seattle, USA
Post-doctoral fellow working with Prof. Ruedi Aebersold
2004-2006, Dalian Institute of Chemical Physics, CAS, Dalian, China
Associate Research Professor
2006-present, Dalian Institute of Chemical Physics, CAS, Dalian, China
Research Professor
Research interests
1) New proteomics approaches for analysis of protein post-translational modifications
2) New proteomics approaches to elucidate the interaction between small molecules and proteins
3) Mass spectrometry-based approach for identification and quantification of proteins